Title : Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling.

Pub. Date : 2006 Mar 1

PMID : 16288880






1 Functional Relationships(s)
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1 In PARP enzyme assays using recombinant PARP-1 and PARP-2, the quinazolinone derivatives displayed relatively high selectivity for PARP-1 and quinoxaline derivatives showed superior selectivity for PARP-2, and the quinazolidinone derivatives did not have selectivity for PARP-1/2. Quinazolinones poly(ADP-ribose) polymerase family member 12 Homo sapiens