Title : Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis.

Pub. Date : 2006 Apr 15

PMID : 16287099






4 Functional Relationships(s)
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Protein Name
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1 Inhibition of E6-mediated p53 proteasomal degradation by MG132 resulted in elevated levels of active p53 as demonstrated by p53 small interfering RNA (siRNA) sensitive p21 upregulation. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens
2 Inhibition of E6-mediated p53 proteasomal degradation by MG132 resulted in elevated levels of active p53 as demonstrated by p53 small interfering RNA (siRNA) sensitive p21 upregulation. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens
3 Inhibition of E6-mediated p53 proteasomal degradation by MG132 resulted in elevated levels of active p53 as demonstrated by p53 small interfering RNA (siRNA) sensitive p21 upregulation. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens
4 Although p53 siRNA partially inhibited MG132-induced DR5 upregulation in HeLa and SiHa, no effect on rhTRAIL-induced apoptosis was observed. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens