Title : pH-induced reversible conformational and morphological regulation of polyleucine grafted polyallylamine assembly in solution.

Pub. Date : 2005 Nov 22

PMID : 16285826






1 Functional Relationships(s)
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1 Under acidic conditions, where electrostatic repulsion existed between the neighboring protonated amine moieties of the polyallylamine main chain, the rapid aggregation of the poly(l-leucine) graft chains was disturbed, and the peptide graft chains formed a beta-sheet structure owing to the intramolecular hydrogen bonding among the graft chains. polyallylamine amyloid beta precursor protein Homo sapiens