Pub. Date : 2005 Nov
PMID : 16283513
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression. | Nickel | vascular endothelial growth factor A | Homo sapiens |
| 2 | Previous studies have revealed that nickel compounds can induce the expression of vascular endothelial growth factor (VEGF), which is a key mediator of angiogenesis both in physiological and pathologic conditions. | Nickel | vascular endothelial growth factor A | Homo sapiens |
| 3 | Previous studies have revealed that nickel compounds can induce the expression of vascular endothelial growth factor (VEGF), which is a key mediator of angiogenesis both in physiological and pathologic conditions. | Nickel | vascular endothelial growth factor A | Homo sapiens |
| 4 | In the present study, we investigated the potential roles of PI-3K, ERKs, p38 kinase and calcium signalling in VEGF induction by nickel in Cl 41 cells. | Nickel | vascular endothelial growth factor A | Homo sapiens |
| 5 | Exposure of Cl 41 cells to nickel compounds led to VEGF induction in both time- and dose-dependent manners. | Nickel | vascular endothelial growth factor A | Homo sapiens |
| 6 | Pre-treatment of Cl 41 cells with PI-3K inhibitor, wortmannin or Ly294002, resulted in a striking inhibition of VEGF induction by nickel compounds, implicating the role of PI-3K in the induction. | Nickel | vascular endothelial growth factor A | Homo sapiens |
| 7 | Pre-treatment of Cl 41 cells with intracellular calcium chelator, but not calcium channel blocker, inhibited VEGF induction by nickel. | Nickel | vascular endothelial growth factor A | Homo sapiens |
| 8 | Collectively these data demonstrate that PI-3K, ERKs and cytosolic calcium, but not p38 kinase, play essential roles in VEGF induction by nickel compounds. | Nickel | vascular endothelial growth factor A | Homo sapiens |