Title : Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity.

Pub. Date : 2006 Jan

PMID : 16283431






3 Functional Relationships(s)
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1 Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity. Arsenic Trioxide mitogen-activated protein kinase 8 Homo sapiens
2 In contrast, JNK inhibitor enhanced the As2O3-induced p21 activation, also in a dose-dependent fashion. Arsenic Trioxide mitogen-activated protein kinase 8 Homo sapiens
3 Therefore, we conclude that in A431 cells the ERK1/2 and JNK pathways might differentially contribute to As2O3-induced p21 expression and then due to cellular cytotoxicity. Arsenic Trioxide mitogen-activated protein kinase 8 Homo sapiens