Title : Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity.

Pub. Date : 2006 Jan

PMID : 16283431






2 Functional Relationships(s)
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1 The As2O3-induced p21 activation was attenuated by inhibitors of EGFR and MEK in a dose-dependent manner. Arsenic Trioxide mitogen-activated protein kinase kinase 7 Homo sapiens
2 Furthermore, MEK inhibitor attenuated the anti-tumor effect of As2O3. Arsenic Trioxide mitogen-activated protein kinase kinase 7 Homo sapiens