Pub. Date : 2006 Feb
PMID : 16280384
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aflatoxin B1 alters the expression of p53 in cytochrome P450-expressing human lung cells. | Aflatoxin B1 | tumor protein p53 | Homo sapiens |
| 2 | Mutations (and altered expression) of the tumor suppresser gene p53 have been observed in liver tumors from patients exposed to high dietary AFB1. | Aflatoxin B1 | tumor protein p53 | Homo sapiens |
| 3 | We examined the effects of low concentrations of AFB1 on the expression of p53 and MDM2 in human bronchial epithelial cells (BEAS-2B) transfected with cDNA for either cytochrome P450 (CYP) 1A2 (B-CMV1A2) or CYP 3A4 (B3A4), two isozymes that are responsible for AFB1 activation in human liver and possibly the lung. | Aflatoxin B1 | tumor protein p53 | Homo sapiens |