Title : Effect of Cimetidine and Phenobarbital on metabolite kinetics of Omeprazole in rats.

Pub. Date : 2005 Oct

PMID : 16276979






1 Functional Relationships(s)
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1 These results indicate that CMT inhibits the OMP metabolism due to both decreased hepatic blood flow and inhibited enzyme activity of CYP2C19 and 3A4 and that PB increases the OMP metabolism due to stimulation of the liver blood flow and/or bile flow, due not to induction of the enzyme activity of CYP3A4. Phenobarbital cytochrome P450 family 3 subfamily A member 4 Homo sapiens