Pub. Date : 2006 Mar
PMID : 16272460
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TNF-alpha sensitizes normal and fibrotic human lung fibroblasts to Fas-induced apoptosis. | ammonium ferrous sulfate | tumor necrosis factor | Homo sapiens |
| 2 | Using normal and fibrotic human lung fibroblasts and the human lung fibroblast cell line, MRC-5, we examined the regulation of Fas-induced apoptosis by the proinflammatory cytokines TNF-alpha and IFN-gamma. | ammonium ferrous sulfate | tumor necrosis factor | Homo sapiens |
| 3 | Herein, we show that the basal resistance of lung fibroblasts and myofibroblasts to Fas-induced apoptosis is overcome by sensitization with TNF-alpha. | ammonium ferrous sulfate | tumor necrosis factor | Homo sapiens |
| 4 | Sensitization by TNF-alpha was observed in MRC-5 cells and in fibroblasts and myofibroblasts from normal and fibrotic human lung, suggesting that this represents a conserved mechanism to engage Fas-induced apoptosis. | ammonium ferrous sulfate | tumor necrosis factor | Homo sapiens |