Pub. Date : 2005 Nov 15
PMID : 16272352
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resolution of inflammation: prostaglandin E2 dissociates nuclear trafficking of individual NF-kappaB subunits (p65, p50) in stimulated rheumatoid synovial fibroblasts. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | We tested whether PGE2 regulated nuclear localization of individual NF-kappaB subunits, p65 and p50, in synovial fibroblasts harvested from patients with rheumatoid arthritis (RA). | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | PGE2 (10 nM, 6 h) enhanced p50, but inhibited p65 translocation and NF-kappaB activation. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | In contrast, depletion of endogenous PGE2 by ibuprofen (100 microM) and celecoxib (5 microM) enhanced p65, but inhibited p50 nuclear translocation as well as binding to NF-kappaB DNA binding sites. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 7 | PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 8 | PGE2 also blocked IL-1beta/TNF-alpha-stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |