Pub. Date : 2005 Oct
PMID : 16266470
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Association of polymorphism in alpha-adducin gene with antihypertensive effect of Hydrochlorothiazide]. | Hydrochlorothiazide | adducin 1 | Homo sapiens |
| 2 | OBJECTIVE: To explore the association between G614T single nuclear polymorphism (SNP) of the alpha-adducin gene and the antihypertensive effect of hydrochlorothiazide (HCTZ) in essential hypertensive (EH) patients. | Hydrochlorothiazide | adducin 1 | Homo sapiens |
| 3 | OBJECTIVE: To explore the association between G614T single nuclear polymorphism (SNP) of the alpha-adducin gene and the antihypertensive effect of hydrochlorothiazide (HCTZ) in essential hypertensive (EH) patients. | Hydrochlorothiazide | adducin 1 | Homo sapiens |
| 4 | RESULTS: After 6 weeks of HCTZ treatment, the decreases in DBP and MAP of patients carrying 614T allele of alpha-adducin were significantly greater than that of those carrying GG homozygotes (P < 0.05). | Hydrochlorothiazide | adducin 1 | Homo sapiens |
| 5 | CONCLUSION: The present study suggests that the alpha-adducin G614T polymorphism is associated with the antihypertensive effect of HCTZ, which is more effective in patients with TT genotype. | Hydrochlorothiazide | adducin 1 | Homo sapiens |