Title : Depsipeptide-resistant KU812 cells show reversible P-glycoprotein expression, hyper-acetylated histones, and modulated gene expression profile.

Pub. Date : 2006 Jun

PMID : 16260035






3 Functional Relationships(s)
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1 P-gp expression returned to the parental cell level when resistant cells were cultured in depsipeptide-free medium, while resistant cells cultured in the medium containing 16 nM depsipeptide still showed hyper-acetylation of histones. Depsipeptides ATP binding cassette subfamily B member 1 Homo sapiens
2 Among the 28 genes that were upregulated, 15 genes also showed an increased expression in parental cells treated with 4 nM depsipeptide for 48 h, while the other 13 genes including P-gp were different. Depsipeptides ATP binding cassette subfamily B member 1 Homo sapiens
3 These findings suggest that continuous exposure to depsipeptide reversibly induces P-gp, which contributes to the onset of resistance, but the altered gene expression profile of resistant cells may also play a role. Depsipeptides ATP binding cassette subfamily B member 1 Homo sapiens