Title : The inhibition of neutrophil-endothelial cell adhesion by hyaluronan independent of CD44.

Pub. Date : 2005

PMID : 16259720






2 Functional Relationships(s)
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1 The recent discovery that ICAM-1 binds hyaluronan and exhibits the B(X(7))B HA binding motif, led us also to investigate whether cell adhesion could be modulated by hyaluronan. Hyaluronic Acid intercellular adhesion molecule 1 Homo sapiens
2 CONCLUSIONS: These results show that hyaluronan, at concentrations below those where intra-molecular associations occur, binds selectively to stimulated endothelial cells and inhibits neutrophil adhesion in vitro and in vivo via a mechanism which may involve molecules other than CD44, such as ICAM-1. Hyaluronic Acid intercellular adhesion molecule 1 Homo sapiens