Pub. Date : 2005 Nov 7
PMID : 16253239
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells. | edelfosine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | Contrary to this notion, we have found that a novel alkylphospholipid type antitumor agent ET-18-O-CH3 (1-O-octadecyl-2-O-methyl-glycero-3-phosphocholine) induces COX-2 expression in H-ras transformed human breast epithelial cells (MCF10A-ras) while it causes apoptosis at the same concentration range. | edelfosine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | ET-18-O-CH3 enhanced the transcriptional activities of cyclic AMP response element which is a key regulator of COX-2 expression. | edelfosine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | Based on these findings, it is likely that ET-18-O-CH3 induces COX-2 expression and production of 15d-PGJ2 which may mediate the ET-18-O-CH3-induced apoptosis in MCF10A-ras cells. | edelfosine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |