Title : Effect of omeprazole on the hydroxylation of warfarin enantiomers in human: in-vitro studies with liver microsomes and cDNA-expressed cytochrome P450 isozymes.

Pub. Date : 2005 Oct

PMID : 16248835






1 Functional Relationships(s)
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1 Further study conducted in cDNA-expressed cytochrome P450s (CYPs) demonstrates that the inhibition of the in-vitro biotransformation of warfarin enantiomers by omeprazole is attributed to its inhibitory effect on the activities of CYP1A2, CYP3A4, CYP2C9 and CYP2C19. Warfarin cytochrome P450 family 1 subfamily A member 2 Homo sapiens