Title : Prostaglandins and ulcer healing.

Pub. Date : 2005 Sep

PMID : 16247187






3 Functional Relationships(s)
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1 Dexamethasone, that decreases the expression of COX-2 and mucosal generation of PGE(2), delays ulcer healing that can be reversed by the addition of small dose of exogenous PGE(2). Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 The ulcer healing activity of growth factors (e.g. EGF, TGF alpha, HGF) and certain gut hormones (gastrin, CCK) as well as melatonin, can be attenuated by treatment with COX-1 or COX-2 inhibitors which suppress the release of PGE(2) but enhance the expression of COX-2. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens