Pub. Date : 2005 Sep
PMID : 16247187
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexamethasone, that decreases the expression of COX-2 and mucosal generation of PGE(2), delays ulcer healing that can be reversed by the addition of small dose of exogenous PGE(2). | Prostaglandins E | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa. | Prostaglandins E | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | The ulcer healing activity of growth factors (e.g. EGF, TGF alpha, HGF) and certain gut hormones (gastrin, CCK) as well as melatonin, can be attenuated by treatment with COX-1 or COX-2 inhibitors which suppress the release of PGE(2) but enhance the expression of COX-2. | Prostaglandins E | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |