Title : Hexa-acylation and KDO(2)-glycosylation determine the specific immunostimulatory activity of Neisseria meningitidis lipid A for human monocyte derived dendritic cells.

Pub. Date : 2006 Feb 27

PMID : 16246469






1 Functional Relationships(s)
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1 These data suggest that KDO linked to a fully acylated meningococcal lipid A is required for meningococcal endotoxin"s immunostimulatory activity of human MDDC via TLR4/MD-2 and that different endotoxin structures influence Th responses mediated by MDDC. Lipid A toll like receptor 4 Homo sapiens