Title : P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils.

Pub. Date : 2005 Oct 25

PMID : 16243036






1 Functional Relationships(s)
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1 Here, we characterized P-Rex1, a Gbetagamma and PIP(3)-regulated guanine nucleotide exchange factor that was initially identified as a Rac activator in response to chemoattractants, for its roles in the regulation of Rac activity and neutrophil functions. pip(3) phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 Mus musculus