Title : Faster lactate transport across red blood cell membrane in sickle cell trait carriers.

Pub. Date : 2006 Feb

PMID : 16239612






5 Functional Relationships(s)
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1 Lactate influxes [total lactate influx and monocarboxylate transporter (MCT-1)-mediated lactate influx] into erythrocytes were measured at four external [14C]-labeled lactate concentrations (1.6, 8.1, 41, and 81.1 mM). Lactic Acid solute carrier family 16 member 1 Homo sapiens
2 Lactate influxes [total lactate influx and monocarboxylate transporter (MCT-1)-mediated lactate influx] into erythrocytes were measured at four external [14C]-labeled lactate concentrations (1.6, 8.1, 41, and 81.1 mM). Lactic Acid solute carrier family 16 member 1 Homo sapiens
3 Total lactate influx and lactate influx via the MCT-1 pathway were significantly higher in AS compared with AA at 1.6, 41, and 81.1 mM. Lactic Acid solute carrier family 16 member 1 Homo sapiens
4 The maximal lactate transport capacity for MCT-1 was higher in AS than in AA. Lactic Acid solute carrier family 16 member 1 Homo sapiens
5 The higher MCT-1 maximal lactate transport capacity found in AS suggests greater content or greater activity of MCT-1 in AS RBC membranes. Lactic Acid solute carrier family 16 member 1 Homo sapiens