Pub. Date : 2006 Mar
PMID : 16236819
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have shown that acute hypoxia selectively inhibits I(K(V)) through KCNA5 channels in PASMC. | pasmc | potassium voltage-gated channel subfamily A member 5 | Homo sapiens |
| 2 | Overexpression of the human KCNA5 gene increased I(K(V)) and caused membrane hyperpolarization in HEK-293, COS-7, and rat MASMC and PASMC. | pasmc | potassium voltage-gated channel subfamily A member 5 | Homo sapiens |
| 3 | However, overexpression of KCNA5 in PASMC conferred its sensitivity to hypoxia. | pasmc | potassium voltage-gated channel subfamily A member 5 | Homo sapiens |
| 4 | Reduction of Po(2) from 145 to 35 mmHg reduced I(K(V)) by approximately 40% in rat PASMC transfected with human KCNA5 but had no effect on I(K(V)) in KCNA5-transfected rat MASMC (or HEK and COS cells). | pasmc | potassium voltage-gated channel subfamily A member 5 | Homo sapiens |
| 5 | These results indicate that KCNA5 is an important Kv channel that regulates resting membrane potential and that acute hypoxia selectively reduces KCNA5 channel activity in PASMC relative to MASMC and other cell types. | pasmc | potassium voltage-gated channel subfamily A member 5 | Homo sapiens |