Pub. Date : 2006 Jan
PMID : 16236797
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain. | Phosphatidylinositol 4,5-Diphosphate | protein kinase C alpha | Homo sapiens |
| 2 | We find that Ca2+-activated PKCalpha and its isolated C2 domain localize exclusively to the plasma membrane in vivo and that a plasma membrane lipid, phosphatidylinositol-4,5-bisphosphate (PIP2), dramatically enhances the Ca2+-triggered binding of the C2 domain to membranes in vitro. | Phosphatidylinositol 4,5-Diphosphate | protein kinase C alpha | Homo sapiens |
| 3 | Similarly, a hybrid construct substituting the PKCalpha Ca2+-binding loops (CBLs) and PIP2 binding site (beta-strands 3-4) into a different C2 domain exhibits native Ca2+-triggered targeting to plasma membrane and recognizes PIP2. | Phosphatidylinositol 4,5-Diphosphate | protein kinase C alpha | Homo sapiens |
| 4 | Similarly, a hybrid construct substituting the PKCalpha Ca2+-binding loops (CBLs) and PIP2 binding site (beta-strands 3-4) into a different C2 domain exhibits native Ca2+-triggered targeting to plasma membrane and recognizes PIP2. | Phosphatidylinositol 4,5-Diphosphate | protein kinase C alpha | Homo sapiens |