Title : Effect of gene disruptions of the TCA cycle on production of succinic acid in Saccharomyces cerevisiae.

Pub. Date : 1999

PMID : 16232421






1 Functional Relationships(s)
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1 When cultured in YPD medium containing 15% glucose under aerobic conditions, the KGD1 (alpha-ketoglutarate dehydrogenase) gene disrupted mutant produced a lower level of succinate than the wild-type strain, while the SDH1 (succinate dehydrogenase) gene-disrupted mutant produced an increased level of succinate. ypd medium alpha-ketoglutarate dehydrogenase KGD1 Saccharomyces cerevisiae S288C