Title : Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes.

Pub. Date : 2005 Oct 15

PMID : 16230390






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The induction of cyclin D1 by arsenite required nuclear factor-kappaB (NF-kappaB) activation, because the inhibition of IkappaB phosphorylation by overexpression of the dominant-negative mutant, IKKbeta-KM, impaired arsenite-induced cyclin D1 expression and G1-S transition. arsenite inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens
2 Taken together, our results show that arsenite-induced cell cycle from G(1) to S phase transition is through IKKbeta/NF-kappaB/cyclin D1-dependent pathway. arsenite inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens