Title : Procainamide is a specific inhibitor of DNA methyltransferase 1.

Pub. Date : 2005 Dec 9

PMID : 16230360






1 Functional Relationships(s)
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1 At micromolar concentrations, procainamide was found to be a partial competitive inhibitor of DNMT1, reducing the affinity of the enzyme for its two substrates, hemimethylated DNA and S-adenosyl-l-methionine. S-Adenosylmethionine DNA methyltransferase 1 Homo sapiens