Title : Renal effects of long-term leptin infusion and preventive role of losartan treatment in rats.

Pub. Date : 2005 Dec 15

PMID : 16229907






2 Functional Relationships(s)
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1 ET-1 levels were also reversed to the normal values with the losartan treatment. Losartan endothelin 1 Rattus norvegicus
2 Na and Cr excretions were decreased, while proteinuria and plasma ET-1 levels were normalized by losartan treatment, suggesting that renin-angiotensin system activation may have a role in leptin induced renal changes. Losartan endothelin 1 Rattus norvegicus