Title : WMC-79, a potent agent against colon cancers, induces apoptosis through a p53-dependent pathway.

Pub. Date : 2005 Oct

PMID : 16227412






1 Functional Relationships(s)
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1 The recruitment of the p53-dependent apoptosis pathway was suggested by the up-regulation of p53, p21, Bax, DR-4, DR-5, and p53 phosphorylated on Ser15; down-regulation of Bcl-2; and activation of caspase-8, -9, -7, and -3 in cells treated with 100 nmol/L WMC-79. wmc tumor protein p53 Homo sapiens