Pub. Date : 2005 Dec
PMID : 16219028
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cocaine-induced CREB phosphorylation in nucleus accumbens of cocaine-sensitized rats is enabled by enhanced activation of extracellular signal-related kinase, but not protein kinase A. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 2 | Cocaine-induced CREB phosphorylation in nucleus accumbens of cocaine-sensitized rats is enabled by enhanced activation of extracellular signal-related kinase, but not protein kinase A. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 3 | We hypothesized that the same treatment regimen would also enhance cocaine-induced activation of intracellular signaling kinases that phosphorylate cyclic AMP-regulated element-binding protein (CREB), an important mediator of c-fos transcription. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 4 | We hypothesized that the same treatment regimen would also enhance cocaine-induced activation of intracellular signaling kinases that phosphorylate cyclic AMP-regulated element-binding protein (CREB), an important mediator of c-fos transcription. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 5 | Using western blots and immunohistochemistry, we detected cocaine-induced CREB phosphorylation after repeated cocaine administration, but not after repeated saline administration. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 6 | Using western blots and immunohistochemistry, we detected cocaine-induced CREB phosphorylation after repeated cocaine administration, but not after repeated saline administration. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 7 | Unilateral infusions of the MAPK kinase inhibitor U0126 into nucleus accumbens attenuated cocaine-induced ERK and CREB phosphorylation in cocaine-sensitized rats. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 8 | Therefore, enhanced activation of ERK, but not PKA, enables and mediates cocaine-induced CREB phosphorylation in nucleus accumbens of rats that are sensitized by repeated cocaine administration outside their home cages. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 9 | Therefore, enhanced activation of ERK, but not PKA, enables and mediates cocaine-induced CREB phosphorylation in nucleus accumbens of rats that are sensitized by repeated cocaine administration outside their home cages. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |