Title : Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study.

Pub. Date : 2005 Dec

PMID : 16214825






5 Functional Relationships(s)
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1 Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study. Azathioprine inosine triphosphatase Homo sapiens
2 RESULTS: Early drop-out (within 2 weeks) from aza therapy was associated with ITPA 94C > A [P = 0.020; odds ratio (OR), 4.6; 95% confidence interval (95% CI), 1.2-17.4] and low TPMT activity [<10 nmol/(mL erythrocytes . Azathioprine inosine triphosphatase Homo sapiens
3 For only drop-outs attributable to aza-related side effects (n = 16), there was a significant association with ITPA 94C > A (P = 0.002; OR = 7.8; 95% CI, 2.1-29.1). Azathioprine inosine triphosphatase Homo sapiens
4 CONCLUSIONS: Patients with ITPA 94C > A mutations or low TPMT activity constitute a pharmacogenetic high-risk group for drop-out from aza therapy. Azathioprine inosine triphosphatase Homo sapiens
5 ITPA 94C>A appears to be a promising marker indicating predisposition to aza intolerance. Azathioprine inosine triphosphatase Homo sapiens