Title : Modification of eicosanoid profile in human blood treated by dual COX/LOX inhibitors.

Pub. Date : 2005 Dec

PMID : 16213697






1 Functional Relationships(s)
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1 In this study, using reference COX-2, 5-LOX and dual COX-2/5-LOX inhibitors, we devised a protocol which permitted the simultaneous quantification of eicosanoid metabolites formed during stimulation of human peripheral venous blood samples with the calcium ionophore, A23187, in the absence and presence of lipopolysaccharide (LPS). Eicosanoids mitochondrially encoded cytochrome c oxidase II Homo sapiens