Title : Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation.

Pub. Date : 2005 Dec

PMID : 16210565






1 Functional Relationships(s)
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1 METHODS AND RESULTS: Through the use of 2 functional models, aortic rings and intravital video microscopy of the cremaster, we found that arterial relaxation in response to the endothelium-dependent vessel relaxant, acetylcholine or the nitric oxide synthase (NOS) activator (A23187), was significantly impaired in cystathionine beta-synthase null (CBS(-/-)) mice. Acetylcholine cystathionine beta-synthase Mus musculus