Title : Blockade of AT1 receptors in the rostral ventrolateral medulla increases sympathetic activity under hypoxic conditions.

Pub. Date : 2006 Mar

PMID : 16210417






1 Functional Relationships(s)
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1 In urethane-anesthetized rats, microinjections of the AT1 receptor antagonist candesartan in the RVLM during moderate hypoxia unexpectedly resulted in substantial increases in arterial pressure and renal sympathetic nerve activity (RSNA), whereas under normoxic conditions the same dose resulted in no significant change in arterial pressure and RSNA. candesartan angiotensin II receptor, type 1a Rattus norvegicus