Title : Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.

Pub. Date : 2006 Mar 15

PMID : 16206275






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. beta Carotene mitogen-activated protein kinase 3 Homo sapiens
2 Using a cell line derived from a human pulmonary adenocarcinoma (PAC) of Clara cell lineage and immortalized human small airway epithelial cells, our data show that low concentrations of beta-carotene that can be realistically expected in human tissues after oral administration caused a significant increase in intracellular cAMP and activated PKA, as well as in phosphorylation of ERK1/2 and CREB. beta Carotene mitogen-activated protein kinase 3 Homo sapiens