Pub. Date : 2005 Oct 1
PMID : 16204068
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In contrast, irinotecan (CPT-11) and tomudex sensitized p53 WT, mutant, and null cells to Fas-mediated cell death. | Irinotecan | tumor protein p53 | Homo sapiens |
| 2 | In contrast, irinotecan (CPT-11) and tomudex sensitized p53 WT, mutant, and null cells to Fas-mediated cell death. | Irinotecan | tumor protein p53 | Homo sapiens |
| 3 | Furthermore, CPT-11 and tomudex, but not 5-FU or oxaliplatin, up-regulated Fas cell surface expression in a p53-independent manner. | Irinotecan | tumor protein p53 | Homo sapiens |
| 4 | In addition, increased Fas cell surface expression in p53 mutant and null cell lines in response to CPT-11 and tomudex was accompanied by only a slight increase in total Fas mRNA and protein expression, suggesting that these agents trigger p53-independent trafficking of Fas to the plasma membrane. | Irinotecan | tumor protein p53 | Homo sapiens |
| 5 | Treatment with CPT-11 or tomudex induced STAT1 phosphorylation (Ser727) in the p53-null HCT116 cell line but not the p53 WT cell line. | Irinotecan | tumor protein p53 | Homo sapiens |
| 6 | We conclude that CPT-11 and tomudex may be more effective than 5-FU and oxaliplatin in the treatment of p53 mutant colorectal cancer tumors by sensitizing them to Fas-mediated apoptosis in a STAT1-dependent manner. | Irinotecan | tumor protein p53 | Homo sapiens |