Pub. Date : 2005 Oct 1
PMID : 16204064
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survival. | Topotecan | tumor protein p53 | Homo sapiens |
| 2 | Treatment of p53 wild-type cells with pifithrin-alpha, an inhibitor of the trans-activating activity of p53, caused reversal of the phenotype, making wild-type cells more sensitive to topotecan. | Topotecan | tumor protein p53 | Homo sapiens |
| 3 | Treatment of p53 wild-type cells with pifithrin-alpha, an inhibitor of the trans-activating activity of p53, caused reversal of the phenotype, making wild-type cells more sensitive to topotecan. | Topotecan | tumor protein p53 | Homo sapiens |
| 4 | U138 cells (p53 mutated) were significantly more sensitive to topotecan than U87 cells (p53 wild-type). | Topotecan | tumor protein p53 | Homo sapiens |
| 5 | The data suggests that p53 causes resistance of cells to topo I inhibitors due to stimulation of topotecan-triggered topo I degradation which may impact topotecan-based cancer therapy. | Topotecan | tumor protein p53 | Homo sapiens |
| 6 | The data suggests that p53 causes resistance of cells to topo I inhibitors due to stimulation of topotecan-triggered topo I degradation which may impact topotecan-based cancer therapy. | Topotecan | tumor protein p53 | Homo sapiens |