Title : CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.

Pub. Date : 2005 Nov 18

PMID : 16202979






3 Functional Relationships(s)
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1 Thus, the aim of this study was to clarify the role of CYP1A1 in the suppression of LXR-mediated signal transductions by 3-methlychoranthrene (MC), one of the PAHs. Methylcholanthrene cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 The repression of LXR-mediated signal transductions by MC was restored by co-treatment of HepG2 cells with a CYP1A1 inhibitor, alpha-naphthoflavone, and by the transfection of short interference RNA for CYP1A1. Methylcholanthrene cytochrome P450 family 1 subfamily A member 1 Homo sapiens
3 The repression of LXR-mediated signal transductions by MC was restored by co-treatment of HepG2 cells with a CYP1A1 inhibitor, alpha-naphthoflavone, and by the transfection of short interference RNA for CYP1A1. Methylcholanthrene cytochrome P450 family 1 subfamily A member 1 Homo sapiens