Pub. Date : 2006 Jun
PMID : 16198082
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 2 | The primary CYPs involved in the metabolism and bioactivation of BaP are CYP1A1 and CYP1B1. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 3 | Furthermore, BaP can induce expression of CYP1A1 and CYP1B1 via the aryl hydrocarbon receptor. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 4 | Induction of CYP1A1 and CYP1B1 by BaP in target (lung) and non-target (liver) tissues was investigated utilizing precision-cut rat liver and lung slices exposed to BaP in vitro. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 5 | In vitro exposure of liver and lung slices to BaP resulted in a concentration-dependent increase in CYP1A1 and CYP1B1 mRNA and protein levels, which correlated directly with the exposure-related increase in BaP-DNA adduct levels observed previously in the tissue slices [Harrigan, J.A., Vezina, C.M., McGarrigle, B.P., Ersing, N., Box, H.C., Maccubbin, A.E., Olson, J.R., 2004. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 6 | In vitro exposure of liver and lung slices to BaP resulted in a concentration-dependent increase in CYP1A1 and CYP1B1 mRNA and protein levels, which correlated directly with the exposure-related increase in BaP-DNA adduct levels observed previously in the tissue slices [Harrigan, J.A., Vezina, C.M., McGarrigle, B.P., Ersing, N., Box, H.C., Maccubbin, A.E., Olson, J.R., 2004. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 7 | Pretreatment of animals in vivo with TCDD produced a marked induction of CYP1A1 and CYP1B1 expression in the tissue slices, which was similar to the levels of CYP1A1 and CYP1B1 mRNA achieved in liver and lung following in vivo treatment with BaP. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 8 | Following in vitro exposure to BaP, the levels of CYP1A1 were greater in the lung than the liver, while following all exposures (in vitro and in vivo), the levels of CYP1B1 mRNA were greater in lung tissue compared to liver. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 9 | The higher expression of CYP1A1 and CYP1B1 in the lung was associated with higher levels of BaP-DNA adducts in the lung slices (Harrigan et al. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |