Title : [The clinical and pharmacokinetic evaluation of two-route chemotherapy with cisplatin and sodium thiosulfate in combination with angiotensin II].

Pub. Date : 1992 May

PMID : 1619320






4 Functional Relationships(s)
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1 One hundred-fifty mg of CDDP/body was intraperitoneally administered while the usual systolic blood pressure was increased to 130-140% by AT-II. cddp angiotensinogen Homo sapiens
2 This suggests that, during renal vasoconstriction induced by AT-II, the renal blood flow as well as renal uptake of CDDP was decreased. cddp angiotensinogen Homo sapiens
3 The extreme vasoconstriction in the kidneys and other organs induced by AT-II might have protected these organs from the toxicities of CDDP despite the fact that STS infusion was delayed by 15 minutes after CDDP infusion. cddp angiotensinogen Homo sapiens
4 STS infused immediately after the cessation of AT-II could neutralize the CDDP preventing the occurrence of toxicities. cddp angiotensinogen Homo sapiens