Pub. Date : 2005 Nov
PMID : 16192836
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of valproate on plasma levels of interleukin-6 in healthy male humans. | Valproic Acid | interleukin 6 | Homo sapiens |
| 2 | The present study aimed to determine whether there is a treatment effect of valproate on plasma levels of the pro-inflammatory cytokine, interleukin (IL)-6, in healthy male humans. | Valproic Acid | interleukin 6 | Homo sapiens |
| 3 | Plasma levels of IL-6 were measured in 10 healthy male humans before and after 7 days of treatment with 1000 mg per day of valproate (i.e. 500 mg in the morning and 500 mg in the evening). | Valproic Acid | interleukin 6 | Homo sapiens |
| 4 | We found a significant increase in plasma levels of IL-6 after the 7 days of valproate treatment in healthy male subjects. | Valproic Acid | interleukin 6 | Homo sapiens |
| 5 | Furthermore, there was a significant positive correlation between the changes in plasma IL-6 and blood levels of valproic acid. | Valproic Acid | interleukin 6 | Homo sapiens |
| 6 | The findings of this study are consistent with previous studies on subjects with epilepsy, suggesting a modulating effect of valproate on the pro-inflammatory cytokine IL-6 in humans. | Valproic Acid | interleukin 6 | Homo sapiens |