Title : Identification of cytochrome P450 forms involved in the 4-hydroxylation of valsartan, a potent and specific angiotensin II receptor antagonist, in human liver microsomes.

Pub. Date : 2005 Jun

PMID : 16192110






1 Functional Relationships(s)
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1 For the specific CYP inhibitors or substrates examined (furafylline, diclofenac, S(+)-mephenytoin, quinidine and troleandomycin), only diclofenac inhibited the formation of 4-OH valsartan. furafylline cytochrome P450 family 4 subfamily F member 3 Homo sapiens