Pub. Date : 2005 Nov
PMID : 16190879
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation. | Cholesterol | apolipoprotein E | Mus musculus |
| 2 | In contrast, the hippocampal levels of cholesterol and its precursors lathosterol and desmosterol and metabolite 24S-hydroxycholesterol were lower in apoE-deficient mice that were maintained in a regular environmental than those of corresponding control mice, whereas they were markedly elevated following environmental stimulation. | Cholesterol | apolipoprotein E | Mus musculus |
| 3 | Histological and immunohistochemical experiments revealed that the combined stimulatory effects of apoE deficiency and environmental stimulation on cholesterol metabolism were associated with marked activation of hippocampal astrocytes and with the abnormal accumulation of cholesterol in neurons and astrocytes. | Cholesterol | apolipoprotein E | Mus musculus |
| 4 | Histological and immunohistochemical experiments revealed that the combined stimulatory effects of apoE deficiency and environmental stimulation on cholesterol metabolism were associated with marked activation of hippocampal astrocytes and with the abnormal accumulation of cholesterol in neurons and astrocytes. | Cholesterol | apolipoprotein E | Mus musculus |
| 5 | These findings suggest that apoE plays an important role in the translocation of cholesterol from astrocytes to neurons in vivo and in the regulation and homeostasis of this process. | Cholesterol | apolipoprotein E | Mus musculus |