Title : Can COX-2 inhibitor-induced increase in cardiovascular disease risk be modified by essential fatty acids?

Pub. Date : 2005 Jul

PMID : 16190133






3 Functional Relationships(s)
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1 The inhibitory action of aspirin on COX-1 and COX-2 enzymes enhances the tissue concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Eicosapentaenoic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 The inhibitory action of aspirin on COX-1 and COX-2 enzymes enhances the tissue concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Eicosapentaenoic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 In contrast, increase in the concentrations of DGLA, AA, EPA, and DHA is much less with specific COX-2 inhibitors since they do not block the formation of eicosanoids through COX-1 pathway. Eicosapentaenoic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens