Title : [Transfection of HL-60 cells with CYP3A5 gene induces drug-resistant phenotype].

Pub. Date : 2005 Aug

PMID : 16188140






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Compared with HL-60 and HL-60/pc cells, HL-60/CYP3A5 cells were statistically significantly resistant to daunorubicin, aclacinomycin A, vincristine and harringtonine (resistance multiples were 2.89, 2.01, 4.05 and 2.79 times, respectively, P < 0.05), however the sensitivity to teniposide didn"t change (resistance multiple was 1.04 times). Teniposide cytochrome P450 family 3 subfamily A member 5 Homo sapiens