Pub. Date : 2006 Apr 1
PMID : 16187293
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bleomycin acts through TGF-beta1. | Bleomycin | transforming growth factor beta 1 | Homo sapiens |
| 2 | Bleomycin stimulates the COL1A1 promoter through the distal TGF-beta response element by intracellular and extracellular signaling. | Bleomycin | transforming growth factor beta 1 | Homo sapiens |
| 3 | Bleomycin"s extracellular signaling results from the secretion of more latent TGF-beta produced by lung fibroblasts and cleaved to active TGF-beta extracellularly. | Bleomycin | transforming growth factor beta 1 | Homo sapiens |
| 4 | Bleomycin"s extracellular signaling results from the secretion of more latent TGF-beta produced by lung fibroblasts and cleaved to active TGF-beta extracellularly. | Bleomycin | transforming growth factor beta 1 | Homo sapiens |
| 5 | Since the TGF-beta genes are auto-induced in human embryonic IMR-90 lung fibroblasts, this study indicates an autocrine mechanism to maintain homeostasis in vivo for fibroblasts and other cell types, which produce TGF-beta1 to limit the fibrogenic response to TGF-beta1 and Bleomycin. | Bleomycin | transforming growth factor beta 1 | Homo sapiens |
| 6 | Since the TGF-beta genes are auto-induced in human embryonic IMR-90 lung fibroblasts, this study indicates an autocrine mechanism to maintain homeostasis in vivo for fibroblasts and other cell types, which produce TGF-beta1 to limit the fibrogenic response to TGF-beta1 and Bleomycin. | Bleomycin | transforming growth factor beta 1 | Homo sapiens |