Title : Aldosterone enhances angiotensin II receptor binding and inositol phosphate responses.

Pub. Date : 1992 Jul

PMID : 1618554






5 Functional Relationships(s)
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1 Incubation with aldosterone resulted in enhanced angiotensin II-stimulated phospholipase C activation, as demonstrated by increases in angiotensin II-induced inositol phosphate responses in proportion to the increases in receptor number. Inositol Phosphates angiotensinogen Rattus norvegicus
2 Incubation with aldosterone resulted in enhanced angiotensin II-stimulated phospholipase C activation, as demonstrated by increases in angiotensin II-induced inositol phosphate responses in proportion to the increases in receptor number. Inositol Phosphates angiotensinogen Rattus norvegicus
3 In addition, aldosterone prevented angiotensin II-induced downregulation of angiotensin II surface receptors and angiotensin II desensitization of inositol phosphate formation. Inositol Phosphates angiotensinogen Rattus norvegicus
4 In summary, aldosterone 1) directly increased angiotensin II receptor number, 2) increased angiotensin II-stimulated inositol phosphate responses, and 3) prevented angiotensin II-induced downregulation and desensitization. Inositol Phosphates angiotensinogen Rattus norvegicus
5 In summary, aldosterone 1) directly increased angiotensin II receptor number, 2) increased angiotensin II-stimulated inositol phosphate responses, and 3) prevented angiotensin II-induced downregulation and desensitization. Inositol Phosphates angiotensinogen Rattus norvegicus