Title : Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium.

Pub. Date : 2005 Oct 28

PMID : 16179585






1 Functional Relationships(s)
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1 Activation by cell swelling and AA requires cytochrome P450 (CYP) epoxygenase activity to convert AA to epoxyeicosatrienoic acids (EETs) such as 5,6-EET, 8,9-EET, which both act as direct TRPV4 agonists. epoxyeicosatrienoic acids transient receptor potential cation channel, subfamily V, member 4 Mus musculus