Title : Biphasic effect of prostaglandin E2 in a rat model of esophagitis mediated by EP1 receptors: relation to pepsin secretion.

Pub. Date : 2005

PMID : 16172547






1 Functional Relationships(s)
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1 We conclude that endogenous PGs derived from COX-1 are involved in the mucosal defense of the esophagus and that PGE2 has a biphasic influence on esophageal injury, depending on the dose: a protective effect at low doses and a deleterious effect at high doses, both mediated by EP1 receptors--the latter effect of PGE2 may be brought about by stimulation of the pepsin secretion. Phosphatidylglycerols cytochrome c oxidase I, mitochondrial Rattus norvegicus