Title : Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.

Pub. Date : 2005 Nov 18

PMID : 16172130






5 Functional Relationships(s)
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1 Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. Colforsin Rap guanine nucleotide exchange factor 3 Homo sapiens
2 In this study, we have examined the role of two cAMP downstream effectors protein kinase A (PKA) and Epac, in forskolin-induced macrophage proliferation. Colforsin Rap guanine nucleotide exchange factor 3 Homo sapiens
3 Incubation of macrophages with forskolin also increased Epac1 and Rap1.GTP. Colforsin Rap guanine nucleotide exchange factor 3 Homo sapiens
4 Immunoprecipitation of Epac1 in forskolin-stimulated cells co-immunoprecipitated Rap1, p-Akt(Thr-308), and p-Akt(Ser-473). Colforsin Rap guanine nucleotide exchange factor 3 Homo sapiens
5 We conclude that forskolin mediates cellular proliferation via cAMP-dependent activation of both PKA and Epac. Colforsin Rap guanine nucleotide exchange factor 3 Homo sapiens