Pub. Date : 2006 Mar
PMID : 16169930
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells. | diallyl trisulfide | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Here, we demonstrate that DATS inactivates Akt to trigger apoptosis in prostate cancer cells. | diallyl trisulfide | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Treatment of PC-3/DU145 cells with apoptosis inducing concentration of DATS (40 microM) resulted in a rapid decrease in Ser(473) and Thr(308) phosphorylation of Akt leading to inhibition of its kinase activity. | diallyl trisulfide | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | DATS treatment (40 microM) also caused a decrease in Ser(155) and Ser(136) phosphorylation of BAD (a proapoptotic protein), which is a downstream target of Akt. | diallyl trisulfide | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Ectopic expression of constitutively active Akt conferred statistically significant protection against DATS-induced apoptosis. | diallyl trisulfide | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | In conclusion, the present study demonstrates that DATS-induced apoptosis in human prostate cancer cells is mediated, at least in part, by inactivation of Akt signaling axis. | diallyl trisulfide | AKT serine/threonine kinase 1 | Homo sapiens |