Title : The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism.

Pub. Date : 2006 Jan 1

PMID : 16166589






1 Functional Relationships(s)
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1 Interestingly, enforced Raf or MEK/ERK activation partially diminished adaphostin/MG-132-mediated ROS generation, suggesting the existence of an amplification loop. Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens