Title : Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells.

Pub. Date : 2005 Sep 15

PMID : 16166323






2 Functional Relationships(s)
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1 There is extensive evidence that treatment of SW480 human colon cancer cells with sulindac sulfone (Exisulind, Aptosyn) or the related derivative OSI-461, both of which inhibit cyclic GMP (cGMP)-phosphodiesterases but lack COX-2 inhibitory activity, causes an increase in intracellular levels of cGMP, thus activating protein kinase G (PKG), which then activates pathways that lead to apoptosis. sulindac sulfone prostaglandin-endoperoxide synthase 2 Homo sapiens
2 There is extensive evidence that treatment of SW480 human colon cancer cells with sulindac sulfone (Exisulind, Aptosyn) or the related derivative OSI-461, both of which inhibit cyclic GMP (cGMP)-phosphodiesterases but lack COX-2 inhibitory activity, causes an increase in intracellular levels of cGMP, thus activating protein kinase G (PKG), which then activates pathways that lead to apoptosis. sulindac sulfone prostaglandin-endoperoxide synthase 2 Homo sapiens